部分学术论文

Gene editing & Stem cell领域

1. Interaction between Sympk and Oct4 Promotes Mouse Embryonic Stem Cell Proliferation. Stem Cells. 2019 Feb 23. doi: 10.1002/stem.2992.

2. Genome-wide profiling of adenine base editor specificity by EndoV-seq. Nature Communications. 2019 Jan 8;10(1):67. doi:10.1038/s41467-018- 07988-z.

3. Effective and precise adenine base editing in mouse zygotes. Protein Cell. 2018 Jul 31. doi: 10.1007/s13238-018-0566-z

4. Cationic Polymer-Mediated CRISPR/Cas9 Plasmid Delivery for Genome Editing. Macromol Rapid Commun. 2018 Apr 30:e1800068. doi: 10.1002/marc.201800068.

5. Parental genetic material and oxygen concentration affect hatch dynamics of mouse embryo in vitro. Reprod Biol Endocrinol. 2018 Apr 21;16(1):39. doi: 10.1186/s12958-018-0356-8.

6. Analysis of hpf1 expression and function in early embryonic development of zebrafish. Dev Genes Evol. 2018 Mar;228(2):141-147. 

7. Testis-specific Lypd9 is dispensable for spermatogenesis in mouse. Molecular Reproduction and Development. 10-Dec-2017 

8. Glycerol kinase-like proteins cooperate with Pld6 in regulating sperm mitochondrial sheath formation and male fertility. Cell Discovery (2017) 3, 17030; doi:10.1038/celldisc.2017.30

9. Developmental history and application of CRISPR in human disease. J Gene Med. 2017 

10. Rho GDP-dissociation inhibitor α is a potential prognostic biomarker and controls telomere regulation in colorectal cancer. Cancer Sci. 2017 Apr 17.

11. Effective production of recipient male pigs for spermatogonial stem cell transplantation by intratesticular injection with busulfan. Theriogenology. 2017 Feb;89:365-373 

12. Vitamin C plus hydrogel facilitates bone marrow stromal cell-mediated endometrium regeneration in rats. Stem Cell Res Ther. 2017 Nov 21;8(1):267. 

13. Efficient Production of Gene-Modified Mice using Staphylococcus aureus Cas9. Sci Rep. 2016 Sep 2;6:32565.

14. Questions about NgAgo. Protein Cell. 2016 Nov 15. 

15. Specific Tandem 3'UTR Patterns and Gene Expression Profiles in Mouse Thy1+ Germline Stem Cells. Plos ONE 2015 

16. CRISPR/Cas9 Promotes Functional Study of Testis Specific X-linked Gene in vivo. PLOS ONE 2015 

17.  Actl6a protects embryonic stem cells from differentiating into primitive endoderm. Stem cells 2015 33, 1782-1793.

18. Telomere shortening and DNA damage of embryonic stem cells induced by cigarette smoke. Reprod Toxicol; 35: 89-95, 2012. 

19. Association of telomere length with authentic pluripotency of ES/iPS cells. Cell Res; 21: 779-792, 2011.

20. Germline competency of parthenogenetic embryonic stem cells from immature oocytes of adult mouse ovary. Hum Mol Genet. 2011 Apr 1;20(7):1339-52.

21. Telomere susceptibility to cigarette smoke-induced oxidative damage and chromosomal instability of mouse embryos in vitro. Free Radic Biol Med; 2010 48: 1663-1676.

22. Generation of pluripotent stem cells from eggs of aging mice. Aging Cell; 9: 113-125, 2010

23. Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients. Nature; 464: 292-296, 2010.

24. Effects of cigarette smoke on fertilization and embryo development in vivo. Fertil Steril; 92: 1456-1465, 2009.

25. Birth of parthenote mice directly from parthenogenetic embryonic stem cells. Stem Cells. 2009 Sep;27(9):2136-45.

26. Isolation and culture of primary bovine embryonic stem cell colonies by a novel method. J Exp Zool A Ecol Genet Physiol. 2009 Jun 1;311(5):368-76.

27. Correlation of expression and methylation of imprinted genes with pluripotency of parthenogenetic embryonic stem cells. Hum Mol Genet. 2009 Jun 15;18(12):2177-87.

28. Efficient production of mice from embryonic stem cells injected into four- or eight- cell embryos by piezo micromanipulation. Stem Cells; 2008 26: 1883-1890.

RNA & Oncology领域

1. Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development. Nature Communications, 2017, 8:783. 
   

2. BAP1 inhibits the ER stress gene regulatory network and modulates metabolic stress response. PNAS, 2017, 114:3192-3197. 
   

3. LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress. Nature Cell Biology, 2016, 18:431–442. 

4. NBR2: A former junk gene emerges as a key player in tumor suppression. Molecular & Cellular Oncology. 2016, 3:e1187322.

5. Long non-coding RNAs in cancer metabolism. Bioessays, 2016, 38:991-996. 

6. BAF180 regulates cellular senescence and hematopoietic stem cell homeostasis through p21. Oncotarget. 2016, 7:19134–19146. 

7. An lncRNA switch for AMPK activation. Cell Cycle. 2016, 15:1948-1949.

8. AMPK modulates Hippo pathway activity to regulate energy homeostasis. Nature Cell Biology, 2015, 17:490-499. 

9. Conservation and divergence of transcriptional co-regulations between box C/D snoRNA and ribosomal protein genes in Ascomycota. RNA, 2014, 20:1376-1385. 

10. Deciphering the transcriptional regulation of microRNA genes in humans with ACTLocater. Nucleic Acids Research, 2013, 41:e5. 

11. β-catenin/LEF1 transactivates the microRNA-371-373 cluster that modulates the Wnt/β-catenin signaling pathway. Oncogene,2012, 31:2968-2978.

12. Liver-enriched transcription factors regulate microRNA-122 that targets CUTL1 during liver development. Hepatology, 2010, 52: 1431-1442. 

13. SnoRNAs from the filamentous fungus Neurospora crassa: structural, functional and evolutionary insights. BMC Genomics, 2009, 10: 515. 

14. Identification of novel chicken microRNAs and analysis of their genomic organization. Gene, 2008, 418:34-40. 

15. Identification of three novel noncoding RNAs from Drosophila melanogaster. Chinese Science Bulletin, 2006, 51: 2737-2742.

Genomics领域

1. Identification of a de novo fetal variant in osteogenesis imperfecta by targeted sequencing-based noninvasive prenatal testing. J Hum Genet. 2018 Aug 21. 
   

2. Multicenter cross-sectional screening of the BRCA gene for Chinese high hereditary risk breast cancer populations.  Oncol Lett. 2018 Jun;15(6):9420-9428. Epub 2018 Apr 18.

3. Germline mutations in 40 cancer susceptibility genes among Chinese patients with high hereditary risk breast cancer . Int J Cancer. 2018 May 12. 

4. DeepNitro: Prediction of Protein Nitration and Nitrosylation Sites by Deep Learning. Genomics Proteomics Bioinformatics. 2018 Aug;16(4):294-306.

5. High resolution global chromosomal aberrations from spontaneous miscarriages revealed by low coverage whole genome sequencing. Eur J Obstet Gynecol Reprod Biol. 2018 Mar 8;224:21-28. 

6. Association of Gene Mutations with Response to Arsenic-Containing Compound Qinghuang Powder in Patients with Myelodysplastic Syndromes. Integr Med. 2018 Apr 4. 

7. Xist-dependent imprinted X inactivation and the early developmental consequences of its failure.  Nat Struct Mol Biol. 2017 Mar;24(3):226-233. 

8. Mutational spectrum and risk stratification of intermediate-risk acute myeloid leukemia patients based on next-generation sequencing.Oncotarget. 2016 May 31;7(22):32065-78.

9. Statistical Approach to Decreasing the Error Rate of Noninvasive Prenatal Aneuploid Detection caused by Maternal Copy Number Variation. Sci Rep. 2015 Nov 4;5:16106.

10. Whole genome sequencing of Ethiopian highlanders reveals conserved hypoxia tolerance genes. Genome Biology. 2014 

11. Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nature Genetics. 2014 Mar;46(3):234-44. doi: 10.1038/ng.2897. 

12. HLA-B*13:01 is associated with salazosulfapyridine-induced drug rash with eosinophilia and systemic symptoms in Chinese Han population. Pharmacogenomics. 11, 1461-1469.

13. Whole-genome sequencing uncovers the genetic basis of chronic mountain sickness in Andean highlanders.  American Journal of Human Genetics. 2013 5; 93(3): 452-62.

14. Circadian gene variants and susceptibility to type 2 diabetes: a pilot study. PLoS One. 2012;7(4)

15. Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. Nature Genetics. 2011 Aug 28;43(10):984-9. doi: 10.1038/ng.921. 

16. Genome-wide gene expression profiling reveals aberrant MAPK and Wnt signaling pathways associated with early parthenogenesis. J Mol Cell Biol. 2010 Dec;2(6):333-44.

17. Association between a polymorphism of the HTR3A gene and therapeutic response to risperidone treatment in drug-naive Chinese schizophrenia patients. Pharmacogenetics. Genomics 18, 721–727.